CD8A (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide, Clone: [C8/1035], Mouse, Monoclonal
Artikelnummer:
ABT-AH12637-U0020
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| Artikelname: | CD8A (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide, Clone: [C8/1035], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH12637-U0020 |
| Hersteller Artikelnummer: | AH12637-U0020 |
| Alternativnummer: | ABT-AH12637-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL |
| CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. |
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