CD20 / MS4A1 (B-Cell Marker) Antibody - With BSA and Azide, Clone: [109-3C2], Mouse, Monoclonal
Artikelnummer:
ABT-AH12671-U0100
- Bilder (0)
| Artikelname: | CD20 / MS4A1 (B-Cell Marker) Antibody - With BSA and Azide, Clone: [109-3C2], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH12671-U0100 |
| Hersteller Artikelnummer: | AH12671-U0100 |
| Alternativnummer: | ABT-AH12671-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20 |
| Recognizes a protein of 30-33kDa, which is identified as CD20 (Workshop V, Code CD20.12. Workshop IV, Code B17). It recognizes an extracellular domain of CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression. |
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