GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide, Clone: [DTA-1], Rat, Monoclonal
Artikelnummer:
ABT-AH12852-U0020
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| Artikelname: | GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide, Clone: [DTA-1], Rat, Monoclonal |
| Artikelnummer: | ABT-AH12852-U0020 |
| Hersteller Artikelnummer: | AH12852-U0020 |
| Alternativnummer: | ABT-AH12852-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Rat |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Mouse |
| Alternative Synonym: | Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr |
| GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ĀCD4+ĀTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ĪŗB activation, and abrogate the inhibitory function ofĀCD25+ĀCD4+ĀTregs. In vivoĀactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response. |
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