CDw17 (Lactosylceramide or LacCer) Antibody - With BSA and Azide, Clone: [HO18.3G-6.F5], Mouse, Monoclonal
Artikelnummer:
ABT-AH12962-U0020
Hersteller Artikelnummer:
AH12962-U0020
Alternativnummer:
ABT-AH12962-U0020-20UG
Hersteller:
Abcepta
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC, IF
Spezies Reaktivität:
Human
CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor Ī (TNFĪ )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[HO18.3G-6.F5]
Antibody Type:
Monoclonal Antibody
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