Anti-Catenin, beta (p120) Antibody, Clone: [12F7], Mouse, Monoclonal
Artikelnummer:
ABT-AH13143-U0020
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| Artikelname: | Anti-Catenin, beta (p120) Antibody, Clone: [12F7], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH13143-U0020 |
| Hersteller Artikelnummer: | AH13143-U0020 |
| Alternativnummer: | ABT-AH13143-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Alternative Synonym: | Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1 |
| Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. |
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