Anti-Catenin, gamma Antibody, Clone: [15F11], Mouse, Monoclonal
Artikelnummer:
ABT-AH13337-U0100
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| Artikelname: | Anti-Catenin, gamma Antibody, Clone: [15F11], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH13337-U0100 |
| Hersteller Artikelnummer: | AH13337-U0100 |
| Alternativnummer: | ABT-AH13337-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, WB |
| Spezies Reaktivität: | Feline, Human, Mouse, Rat |
| Alternative Synonym: | ARVD12, Catenin (cadherin-associated protein), gamma 80kDa, Catenin gamma, CTNNG, Desmoplakin III, Desmoplakin-3, DP3, DPIII, Junction Plakoglobin, PDGB, PKGB |
| It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (alpha, beta, gamma and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy. |
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