Anti-DOG-1 / TMEM16A Antibody, Clone: [DG1/1487R], Rabbit, Monoclonal
Artikelnummer:
ABT-AH13456-U0020
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| Artikelname: | Anti-DOG-1 / TMEM16A Antibody, Clone: [DG1/1487R], Rabbit, Monoclonal |
| Artikelnummer: | ABT-AH13456-U0020 |
| Hersteller Artikelnummer: | AH13456-U0020 |
| Alternativnummer: | ABT-AH13456-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, IHC-P |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A |
| Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%. |
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