Anti-BRCA1 Antibody, Clone: [BRCA1/1472], Mouse, Monoclonal
Artikelnummer:
ABT-AH13528-U0100
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| Artikelname: | Anti-BRCA1 Antibody, Clone: [BRCA1/1472], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH13528-U0100 |
| Hersteller Artikelnummer: | AH13528-U0100 |
| Alternativnummer: | ABT-AH13528-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | ELISA, FC, IF |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53 |
| This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. |
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