RAD17 Antibody - C-terminal region
Artikelnummer:
ASB-ARP30206_T100
- Bilder (3)
| Artikelname: | RAD17 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP30206_T100 |
| Hersteller Artikelnummer: | ARP30206_T100 |
| Alternativnummer: | ASB-ARP30206_T100-25UL,ASB-ARP30206_T100-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Human, Mouse, Porcine, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human RAD17 |
| Alternative Synonym: | CCYC, R24L, RAD24, HRAD17, RAD17SP |
| RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. |
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WB Suggested Anti-RAD17 Antibody Titration: 1.25ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysateRAD17 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells |
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WB Suggested Anti-RAD17 Antibody Positive Control: Lane1: 25ug Hela lysate, Lane2: 25ug HEK293T lysate, Lane3: 25ug Xenopus laevis egg extract, Lane4: 25ug mouse embryonic stem cells lysate Primary Antibody Dilution : 1:500 Secondary Antibody : Anti-rabbit-HRP Secondry Antibody Dilution : 1:3000 Submitted by: Domenico Maiorano, Institute of Human Genetics, CNRS |
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RAD17 antibody - C-terminal region (ARP30206_T100) in Human Jurkat using Western Blot |
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