MXI1 Antibody - middle region
Artikelnummer:
ASB-ARP31402_P050
- Bilder (3)
| Artikelname: | MXI1 Antibody - middle region |
| Artikelnummer: | ASB-ARP31402_P050 |
| Hersteller Artikelnummer: | ARP31402_P050 |
| Alternativnummer: | ASB-ARP31402_P050-25UL,ASB-ARP31402_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human MXI1 |
| Alternative Synonym: | MXI, MAD2, MXD2, bHLHc11 |
| Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. |
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WB Suggested Anti-MXI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: SH-SYSY cell lysateMXI1 is supported by BioGPS gene expression data to be expressed in SHSY5Y |
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Host: Mouse Target Name: MXI1 Sample Tissue: Mouse Testis Antibody Dilution: 1ug/ml |
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MXI1 antibody - middle region (ARP31402_P050) in Human SH-SYSY using Western Blot |
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