The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD4
Alternative Synonym:
AF, ASF, S5A, AF-1, MCB1, Rpn10, pUB-R5
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid.
WB Suggested Anti-PSMD4 Antibody Titration: 0.2-1 ug/ml Positive Control: Raji cell lysatePSMD4 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells
PSMD4 antibody - C-terminal region (ARP32341_P050) in Human Raji using Western Blot
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