MECP2 Antibody - N-terminal region
Artikelnummer:
ASB-ARP32694_P050
- Bilder (3)
| Artikelname: | MECP2 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP32694_P050 |
| Hersteller Artikelnummer: | ARP32694_P050 |
| Alternativnummer: | ASB-ARP32694_P050-25UL,ASB-ARP32694_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Yeast |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human MECP2 |
| Alternative Synonym: | RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13 |
| Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. |
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WB Suggested Anti-MECP2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate |
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Host: Mouse Target Name: MECP2 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml |
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MECP2 antibody - N-terminal region (ARP32694_P050) in Human HepG2 using Western Blot |
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