Rb1 Antibody - middle region
Artikelnummer:
ASB-ARP33211_P050
- Bilder (3)
| Artikelname: | Rb1 Antibody - middle region |
| Artikelnummer: | ASB-ARP33211_P050 |
| Hersteller Artikelnummer: | ARP33211_P050 |
| Alternativnummer: | ASB-ARP33211_P050-25UL,ASB-ARP33211_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of MOUSE Rb1 |
| Alternative Synonym: | R, p, Rb, Rb-, pRb, Rb-1, pp105, p110-RB1 |
| SLC11A1 is key regulator of entry into cell division that acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 Lys-20 trimethylation. Inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex By similarity. |
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Host: Rabbit Target Name: Rb1 Sample Type: Mouse Heart lysates Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target Name: RB1 Sample Tissue: Mouse Brain Antibody Dilution: 7ug/ml |
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Rb1 Antibody - middle region (ARP33211_P050) in Mouse Heart using Western Blot |
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