The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2
Alternative Synonym:
CSN2, SGN2, ALIEN, TRIP15
COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/Ion ChannelSBP. COPS2 is also innvolved in early stage of neuronal differentiation via its interaction with NIF3L1.
Sample Type: 1. Markers 2. B8 mouse fibroblast cells, extraction only 3. Human total cell extract 4. Human blood cells, partially purified 5. Pombe, extraction only Primary Dilution: 1:200 Secondary Anitbody: HRP conjugated anti-rabbit Image Submitted By: Dr. Elah Pick University of Haifa at OranimA
COPS2 antibody - N-terminal region (ARP34189_T100) in Human Jurkat using Western Blot
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