DMTF1 Antibody - C-terminal region
Artikelnummer:
ASB-ARP34602_P050
- Bilder (3)
| Artikelname: | DMTF1 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP34602_P050 |
| Hersteller Artikelnummer: | ARP34602_P050 |
| Alternativnummer: | ASB-ARP34602_P050-25UL,ASB-ARP34602_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human DMTF1 |
| Alternative Synonym: | DMP1, DMTF, MRUL, hDMP1 |
| This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Human Intestine |
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WB Suggested Anti-DMTF1 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysate |
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DMTF1 antibody - C-terminal region (ARP34602_P050) in Human HepG2 using Western Blot |
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