Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat, Yeast
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human TRPC6
Alternative Synonym:
TRP6, FSGS2
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).