PML Antibody - N-terminal region
Artikelnummer:
ASB-ARP38184_P050
- Bilder (3)
| Artikelname: | PML Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP38184_P050 |
| Hersteller Artikelnummer: | ARP38184_P050 |
| Alternativnummer: | ASB-ARP38184_P050-25UL,ASB-ARP38184_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human PML |
| Alternative Synonym: | MYL, RNF71, PP8675, TRIM19 |
| PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteins central and C-terminal regions, all variants encode the same N-terminus. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the proteins central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. |
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WB Suggested Anti-PML Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: MCF7 cell lysate |
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PML antibody - N-terminal region (ARP38184_P050) validated by WB using Neuroblastoma at 1:1000. |
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PML antibody - N-terminal region (ARP38184_P050) in Human MCF7 using Western Blot |
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