SMAD2 Antibody - N-terminal region
Artikelnummer:
ASB-ARP38694_T100
- Bilder (4)
| Artikelname: | SMAD2 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP38694_T100 |
| Hersteller Artikelnummer: | ARP38694_T100 |
| Alternativnummer: | ASB-ARP38694_T100-25UL,ASB-ARP38694_T100-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD2 |
| Alternative Synonym: | JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2 |
| SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. |
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WB Suggested Anti-SMAD2 Antibody Titration: 2.5ug/ml ELISA Titer: 1:1562500 Positive Control: HepG2 cell lysate |
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Lanes: Lane1: 2ug HEK293lysate Lane2: 2ug SMAD2 transfected HEK293 lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-rabbit HRP Secondary Antibody Dilution: 1:5000 Gene Name: SMAD2 Submitted by: Dominique Alfandari, University of Massachusetts |
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Host: Rat Target Name: SMAD2 Sample Tissue: Rat Liver Antibody Dilution: 1ug/ml |
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SMAD2 antibody - N-terminal region (ARP38694_T100) in Human HepG2 using Western Blot |
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