SF3A1 Antibody - N-terminal region
Artikelnummer:
ASB-ARP40615_P050
- Bilder (4)
| Artikelname: | SF3A1 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP40615_P050 |
| Hersteller Artikelnummer: | ARP40615_P050 |
| Alternativnummer: | ASB-ARP40615_P050-25UL,ASB-ARP40615_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IF, IHC, WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human SF3A1 |
| Alternative Synonym: | PRP21, PRPF21, SAP114, SF3A120 |
| SF3A1 is the subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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Sample Type: HeLa Primary Antibody Dilution: 4 ug/ml Secondary Antibody: Anti-rabbit Alexa 546 Secondary Antibody Dilution: 2 ug/ml Gene Name: SF3A1 |
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Rabbit Anti-SF3A1 antibody Catalog Number: ARP40615 Paraffin Embedded Tissue: Human Heart cell Cellular Data: cardiac cell Antibody Concentration: 4.0-8.0 ug/mlMagnification: 400X |
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WB Suggested Anti-SF3A1 Antibody Titration: 0.2-1 ug/ml Positive Control: 721_B cell lysateSF3A1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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SF3A1 antibody - N-terminal region (ARP40615_P050) in Human 721_B using Western Blot |
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