CHFR Antibody - N-terminal region
Artikelnummer:
ASB-ARP43250_P050
- Bilder (4)
| Artikelname: | CHFR Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP43250_P050 |
| Hersteller Artikelnummer: | ARP43250_P050 |
| Alternativnummer: | ASB-ARP43250_P050-25UL,ASB-ARP43250_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CHFR |
| Alternative Synonym: | RNF116, RNF196 |
| CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of Lys-63-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at Lys-63 are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons. |
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Breast |
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WB Suggested Anti-CHFR Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysateCHFR is supported by BioGPS gene expression data to be expressed in HepG2 |
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Host: Rabbit Target: CHFR Positive control (+): Human Lung Tumor (T-LU) Negative control (-): Human Liver Tumor (T-LI) Antibody concentration: 3ug/ml |
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CHFR antibody - N-terminal region (ARP43250_P050) in Human HepG2 using Western Blot |
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