CSTB Antibody - N-terminal region
Artikelnummer:
ASB-ARP45749_P050
- Bilder (3)
| Artikelname: | CSTB Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP45749_P050 |
| Hersteller Artikelnummer: | ARP45749_P050 |
| Alternativnummer: | ASB-ARP45749_P050-25UL,ASB-ARP45749_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Bovine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CSTB |
| Alternative Synonym: | PME, ULD, CST6, EPM1, STFB, CPI-B, EPM1A |
| CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). |
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Immunohistochemistry with Transfected 293T cell lysate tissue at an antibody concentration of 0.25 ug/ml. using anti-CSTB antibody (ARP45749_P050) |
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WB Suggested Anti-CSTB Antibody Titration: 0.25ug/ml Positive Control: 293T cells lysate |
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CSTB antibody - N-terminal region (ARP45749_P050) in Human 293T using Western Blot |
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