Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rat
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human C21orf2
Alternative Synonym:
RDMS, SMDAX, LRRC76, YF5/A2, C21orf2
Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients.