DUT Antibody - N-terminal region
Artikelnummer:
ASB-ARP46028_P050
- Bilder (3)
| Artikelname: | DUT Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP46028_P050 |
| Hersteller Artikelnummer: | ARP46028_P050 |
| Alternativnummer: | ASB-ARP46028_P050-25UL,ASB-ARP46028_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human DUT |
| Alternative Synonym: | dUTPase |
| DUT is an essential enzyme of nucleotide metabolism. This protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. |
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Immunohistochemistry with Jurkat cell lysate tissue |
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WB Suggested Anti-DUT Antibody Titration: 1 ug/ml Positive Control: Fetal Small Intestine cell lysate |
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DUT antibody - N-terminal region (ARP46028_P050) in Human Fetal Small Intestine using Western Blot |
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