SHC1 Antibody - C-terminal region
Artikelnummer:
ASB-ARP50490_P050
- Bilder (3)
| Artikelname: | SHC1 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP50490_P050 |
| Hersteller Artikelnummer: | ARP50490_P050 |
| Alternativnummer: | ASB-ARP50490_P050-25UL,ASB-ARP50490_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human SHC1 |
| Alternative Synonym: | SHC, SHCA |
| SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. |
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WB Suggested Anti-SHC1 Antibody Titration: 0.2-1 ug/ml Positive Control: Human Lung |
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Host: Mouse Target Name: SHC1 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml |
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SHC1 antibody - C-terminal region (ARP50490_P050) in Human Lung using Western Blot |
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