GUCA1A Antibody - N-terminal region
Artikelnummer:
ASB-ARP54309_P050
- Bilder (2)
| Artikelname: | GUCA1A Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP54309_P050 |
| Hersteller Artikelnummer: | ARP54309_P050 |
| Alternativnummer: | ASB-ARP54309_P050-25UL,ASB-ARP54309_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A |
| Alternative Synonym: | COD3, GCAP, GUCA, GCAP1, GUCA1, CORD14, C6orf131 |
| GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. |
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WB Suggested Anti-GUCA1A Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human kidney |
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GUCA1A antibody - N-terminal region (ARP54309_P050) in Human kidney using Western Blot |
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