Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human SENP5
Alternative Synonym:
DKFZp564O1016, FLJ42398, MGC27076
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1, MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates.