EIF3A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
WB Suggested Anti-EIF3A Antibody Titration: 1.0 ug/ml Positive Control: Hela Whole CellThere is BioGPS gene expression data showing that EIF3A is expressed in HeLa
EIF3A antibody - C-terminal region (ARP61702_P050) in Human HeLa using Western Blot
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