PDCD6IP Antibody - C-terminal region
Artikelnummer:
ASB-ARP76945_P050
- Bilder (3)
| Artikelname: | PDCD6IP Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP76945_P050 |
| Hersteller Artikelnummer: | ARP76945_P050 |
| Alternativnummer: | ASB-ARP76945_P050-25UL,ASB-ARP76945_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human PDCD6IP |
| Alternative Synonym: | AIP1, ALIX, HP95, DRIP4 |
| This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. |
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Host: Rabbit Target Name: PDCD6IP Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1.0ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 0.5 ug/mL of the antibody was used in this experiment. |
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