MDM4 Antibody - N-terminal region
Artikelnummer:
ASB-AVARP06007_P050
- Bilder (3)
| Artikelname: | MDM4 Antibody - N-terminal region |
| Artikelnummer: | ASB-AVARP06007_P050 |
| Hersteller Artikelnummer: | AVARP06007_P050 |
| Alternativnummer: | ASB-AVARP06007_P050-25UL,ASB-AVARP06007_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Human, Porcine, Rabbit |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4 |
| Alternative Synonym: | HDMX, MDMX, MRP1, BMFS6 |
| MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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WB Suggested Anti-MDM4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate |
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Lanes: 1. 10 ug MCF7 cell lysate 2. 10 ug MCF7 cell lysate 3. 10 ug MCF7 cell lysate 4. 10 ug MCF7 cell lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-Rabbit HRP Secondary Antibody Dilution: 1:10,000 Gene Name: MDM4 Submitted by: Anonymous |
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MDM4 antibody - N-terminal region (AVARP06007_P050) in Human HepG2 using Western Blot |
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