INSR Antibody - middle region
Artikelnummer:
ASB-AVARP08005_P050
- Bilder (3)
| Artikelname: | INSR Antibody - middle region |
| Artikelnummer: | ASB-AVARP08005_P050 |
| Hersteller Artikelnummer: | AVARP08005_P050 |
| Alternativnummer: | ASB-AVARP08005_P050-25UL,ASB-AVARP08005_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Canine, Equine, Guinea pig, Human, Mouse, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human INSR |
| Alternative Synonym: | HHF5, CD220 |
| This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.A report shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, another report shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. |
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Placenta |
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WB Suggested Anti-INSR Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: THP-1 cell lysate |
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INSR antibody - middle region (AVARP08005_P050) in Human THP-1 using Western Blot |
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