NFKBIA Antibody - middle region
Artikelnummer:
ASB-AVARP09044_P050
- Bilder (3)
| Artikelname: | NFKBIA Antibody - middle region |
| Artikelnummer: | ASB-AVARP09044_P050 |
| Hersteller Artikelnummer: | AVARP09044_P050 |
| Alternativnummer: | ASB-AVARP09044_P050-25UL,ASB-AVARP09044_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Human, Mouse, Porcine, Rat, Sheep |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human NFKBIA |
| Alternative Synonym: | IKBA, MAD-3, NFKBI, EDAID2 |
| NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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WB Suggested Anti-NFKBIA Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 293T cell lysate |
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Lanes: 1. 100 ug mouse heart lysate 2. 100 ug mouse kidney lysate 3. 100 ug mouse lung lysate 4. 100 ug mouse thymus lysate 5. 100 ug mouse spleen lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-rabbit-AP Secondary Antibody Dilution: 1:10000 Gene Name: NFKBIA Submitted by: Andreia Carvalho, Instituto de Biologia Molecular e Celular, Universidade do Porto (IBMC-UP)/Organelle Biogenesis and Function (OBF) Group |
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NFKBIA antibody - middle region (AVARP09044_P050) in Human 293T using Western Blot |
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