The antiserum was produced against synthesized peptide derived from human HIF-1alpha.
Alternative Synonym:
ARNT interacting protein,ARNT-interacting protein,basic-helix-loop-helix-PAS protein MOP1,bHLHe78,class E basic helix-loop-helix protein 78,HIF1,HIF-1A,HIF-1alpha,HIF-1-alpha,HIF1-ALPHA,hypoxia inducible factor 1 alpha subunit,hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),hypoxia-inducible factor 1-alpha,hypoxia-inducible factor1alpha,member of PAS protein 1,member of PAS superfamily 1,MOP1,PAS domain-containing protein 8,PAS domain-containing protein 8, Class E basic helix-loop-helix protein 78, Member of PAS protein 1,PASD8.
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT, heterodimer binds to core DNA sequence 5-TACGTG-3 within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
