Recombinant Human DNA replication licensing factor MCM6 protein (562-821AA)
Konjugation:
Unconjugated
Alternative Synonym:
DNA replication licensing factor MCM6,MCG40308,MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe),minichromosome maintenance deficient (mis5, S. pombe) 6,Mis5,P105MCM.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
