Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)
Konjugation:
Unconjugated
Alternative Synonym:
Hs.89862,TNFR1-associated death domain protein,TNFRSF1A-associated via death domain,tumor necrosis factor receptor type 1 associated death domain protein,tumor necrosis factor receptor type 1-associated DEATH domain protein,tumor necrosis factor receptor-1-associated protein.
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
