Recombinant Human Ras GTPase-activating protein-binding protein 1 protein (227-466AA)
Konjugation:
Unconjugated
Alternative Synonym:
ATP-dependent DNA helicase VIII,DNA helicase VIII,G3BP,G3BP-1,GAP binding protein,GAP SH3 domain-binding protein 1,GTPase activating protein (SH3 domain) binding protein 1,HDH-VIII,ras GTPase-activating protein-binding protein 1,RasGAP-associated endoribonuclease G3BP,Ras-GTPase-activating protein SH3-domain-binding protein.
ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3 tail or hanging tails at both 5- and 3-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5 to 3 direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778).