Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial protein (20-130AA)
Konjugation:
Unconjugated
Alternative Synonym:
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase,NAD-dependent deacetylase sirtuin-3, mitochondrial,NAD-dependent protein deacetylase sirtuin-3, mitochondrial,regulatory protein SIR2 homolog 3,silent mating type information regulation 2, S.cerevisiae, homolog 3,SIR2L3,sir2-like 3,SIR2-like protein 3,sirtuin type 3.
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
