Recombinant Human Zinc finger protein RFP protein (214-513AA)
Konjugation:
Unconjugated
Alternative Synonym:
ret finger protein,RFP,RFP transforming protein,RING finger protein 76,RING-type E3 ubiquitin transferase TRIM27,RNF76,tripartite motif protein TRIM27,tripartite motif-containing protein 27,zinc finger protein RFP.
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity, mediates the formation of Lys-48-linked polyubiquitin chains, the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of Lys-63-linked polyubiquitin chains at Lys-220 of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
