Recombinant Human StAR-related lipid transfer protein 3 protein (170-445AA)
Konjugation:
Unconjugated
Alternative Synonym:
CAB1,es64,metastatic lymph node gene 64 protein,metastatic lymph node protein 64,MLN 64,MLN64,Protein CAB1,StAR-related lipid transfer (START) domain containing 3,stAR-related lipid transfer protein 3,START domain-containing protein 3,steroidogenic acute regulatory protein related.
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences, probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).