TRIM13 Antibody
Artikelnummer:
ASB-OACA07911
- Bilder (3)
| Artikelname: | TRIM13 Antibody |
| Artikelnummer: | ASB-OACA07911 |
| Hersteller Artikelnummer: | OACA07911 |
| Alternativnummer: | ASB-OACA07911-100UL,ASB-OACA07911-50UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, IHC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA) |
| Konjugation: | Unconjugated |
| Alternative Synonym: | B-cell chronic lymphocytic leukemia tumor suppressor Leu5,CAR,CLL-associated RING finger,DLEU5,E3 ubiquitin-protein ligase TRIM13,LEU5,leukemia-associated protein 5,putative tumor suppressor RFP2,ret finger protein 2,RFP2,RING finger protein 77,RING-type E3 ubiquitin transferase TRIM13,RNF77,tripartite motif protein 13,tripartite motif-containing protein 13. |
| Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the Lys-29-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375). |
| Klonalität: | Polyclonal |
| Konzentration: | Varies by lot. See vial for concentration. |
| NCBI: | 10206 |
| Formulierung: | Liquid |
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Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100 |
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Western blot All lanes: TRIM13 antibody at 1.44ug/ml Lane 1: 293T whole cell lysate |
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