NHLRC1 Antibody
Artikelnummer:
ASB-OACA08040
- Bilder (3)
| Artikelname: | NHLRC1 Antibody |
| Artikelnummer: | ASB-OACA08040 |
| Hersteller Artikelnummer: | OACA08040 |
| Alternativnummer: | ASB-OACA08040-100UL,ASB-OACA08040-50UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, IHC, WB |
| Spezies Reaktivität: | Human, Rat |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (1-280AA) |
| Konjugation: | Unconjugated |
| Alternative Synonym: | bA204B7.2,E3 ubiquitin-protein ligase NHLRC1,EPM2A,EPM2B,MALIN,NHL repeat containing 1,NHL repeat-containing protein 1,RING-type E3 ubiquitin transferase NHLRC1. |
| E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. |
| Klonalität: | Polyclonal |
| NCBI: | 378884 |
| Formulierung: | Liquid |
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Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100 |
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Western blot All lanes: NHLRC1 antibody at 3.13ug/ml Lane 1: LO2 whole cell lysate |
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