COMMD1 Antibody
Artikelnummer:
ASB-OACA08176
- Bilder (3)
| Artikelname: | COMMD1 Antibody |
| Artikelnummer: | ASB-OACA08176 |
| Hersteller Artikelnummer: | OACA08176 |
| Alternativnummer: | ASB-OACA08176-100UL,ASB-OACA08176-50UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, IHC, IP, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant Human COMM domain-containing protein 1 protein (1-190AA) |
| Konjugation: | Unconjugated |
| Alternative Synonym: | C2orf5,COMM domain-containing protein 1,copper metabolism (Murr1) domain containing 1,copper metabolism gene MURR1,MURR1,protein Murr1. |
| Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). |
| Klonalität: | Polyclonal |
| Konzentration: | Varies by lot. See vial for concentration. |
| NCBI: | 150684 |
| Formulierung: | Liquid |
|
|
Immunohistochemistry of paraffin-embedded human adrenal gland tissue at dilution 1:100 |
|
|
Immunohistochemistry of paraffin-embedded human liver cancer at dilution 1:100 |
|
|
Western blot All lanes: ACOMMD1antibody at 5.36ug/ml Lane 1A: A549 whole cel |
Produktgarantie und fachkundiger Support
