Recombinant Human Signal transducing adapter molecule 2 protein (376-525AA)
Konjugation:
Unconjugated
Alternative Synonym:
Hbp,Hrs-binding protein,HSE1 homolog,signal transducing adapter molecule 2,signal transducing adaptor molecule (SH3 domain and ITAM motif) 2,STAM-2,STAM2A,STAM2B,STAM-like protein containing SH3 and ITAM domains 2.
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).