Recombinant Human E3 ubiquitin-protein ligase TRIM23 protein (1-280AA)
Konjugation:
Unconjugated
Alternative Synonym:
ADP-ribosylation factor domain protein 1, 64kDa,ADP-ribosylation factor domain-containing protein 1,ARD1,ARF domain protein 1,ARFD1,E3 ubiquitin-protein ligase TRIM23,GTP-binding protein ARD-1,RING finger protein 46,RING-type E3 ubiquitin transferase TRIM23,RNF46,tripartite motif protein TRIM23,tripartite motif-containing protein 23.
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates Lys-27-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
