CD85 antigen-like family member D,CD85D,Ig-like transcript 4,ILT4,ILT-4,Immunoglobulin-like transcript 4,leucocyte Ig-like receptor B2,leukocyte immunoglobulin-like receptor subfamily B member 2,leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2,LIR2,LIR-2,MIR10,MIR-10,monocyte/macrophage immunoglobulin-like receptor 10,myeloid inhibitory receptor 10.
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
