MAP/ERK kinase kinase 1,MAPK/ERK kinase kinase 1,MAPKKK1,MEK kinase 1,MEKK,MEKK 1,MEKK1,mitogen-activated protein kinase kinase kinase 1,mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase,SRXY6.
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).
