CD120a,FPF,p55,p55-R,p60,TBP1,TNFAR,TNF-R,TNFR1,TNF-R1,TNFR55,TNF-R55,TNFR60,TNFR-I,TNF-RI,TNF-R-I,tumor necrosis factor binding protein 1,Tumor necrosis factor receptor 1,tumor necrosis factor receptor superfamily member 1A,tumor necrosis factor receptor type 1,Tumor necrosis factor receptor type I,tumor necrosis factor-alpha receptor.
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
