Recombinant protein encompassing a sequence within the N-terminus region of human MIA3. The exact sequence is proprietary.
Alternative Synonym:
ARNT, D320, ODCD2, TANGO, TANGO1, UNQ6077
Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1.
