Recombinant protein encompassing a sequence within the center region of human TRIB3. The exact sequence is proprietary.
Alternative Synonym:
NIPK, SINK, TRB3, SKIP3, C20orf97
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants.
