Recombinant protein encompassing a sequence within the center region of human EIF4G3. The exact sequence is proprietary.
Alternative Synonym:
eIF4G 3, eIF4GII, eIF-4G 3
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.
