Recombinant protein encompassing a sequence within the center region of human ELAC2. The exact sequence is proprietary.
Alternative Synonym:
ELC2, HPC2, COXPD17
The protein encoded by this gene has a C-terminal domain with tRNA 3&8242, processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
